StarLac®
Premium co-processed Excipient
85 % alpha-lactose monohydrate and 15 % native maize starch
Co-processed excipients (CPEs) play a key role in modern pharmaceutical manufacturing by offering significantly improved functionality compared to conventional excipients. Through the physical combination of established substances – multifunctional particle systems are created with enhanced flowability, compactibility, and reduced sensitivity to lubricants. This leads to improved tablet uniformity and mechanical strength while reducing the need for additional formulation steps. Especially in direct compression, CPEs enable more efficient and robust tablet production, even with high drug loads or poorly compressible APIs. Since they are composed of pharmacopoeial-approved components, regulatory requirements are minimal, further increasing their appeal.
StarLac® combines two excipients that have been firmly established in the pharmaceutical industry for decades: 85 % alpha-lactose monohydrate and 15 % white native corn starch. Both components are of natural origin and are traditionally used as filler and filler with moderate disintegration properties, respectively.
Through innovative co-processing by spray-drying, a novel, monoparticulate excipient is created. StarLac® offers improved tableting performance and enhanced flow properties – ideal for the formulation of oral solid dosage forms.
Benefits
- Excellent compactibility
- Excellent flowability
- Rapid, hardness-independent tablet disintegration
- Compaction and hydration properties do not dendent on hydrophobic lubricant type or level
Areas of Application
- Direct compression
- ODT formulations
- Dry granulation (Roller compaction, slugging)
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- Dry granulation
- Direct compression
- Roller compaction
- Co-processed Excipients
- Oral Solid Dose
- Orally disintegrating tablet (ODT)
- Placebo tablet
- Low to medium dose DC formulation
- Tablet
25kg – Paper bag with PE-EVOH-PE inliner
36 months
Wasserburg am Inn, Germany
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Typical particle size distribution
Typical Product Data
- x10: 44 µm, x50: 169 µm, x90: 277 µm
- Span [(x90-x10)/x50]: 1.38
- Density bulk: 0.578 g/ml
- Density tapped: 0.674 g/ml
- Hausner Ratio: 1.17
- Carr’s Index: 14 %
Specified Product Data
Particle size distribution
Sieve Method: Air-jet sieving
- <32 µm: NMT 15%
- <160 µm: 35-65%
- <250 µm: NLT 80%
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