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The high-functionality excipient, CombiLac® is an integrated, lactose-based, co-processed excipient, specifically designed to ease oral solid dosage form development and manufacture. It is made up of 70 % alpha-lactose monohydrate, 20 % microcrystalline cellulose (MCC) and 10 % white, native corn starch, each conforming with Ph. Eur., USP-NF, JP, ChP compendial requirements.

The three individual components are integrated into a monoparticulate structure, which is not separable by physical means. CombiLac® shows improved compaction properties compared to an equivalent admixture of individual ingredients, providing robust tablets with minimal friability. It assures rapid, hardness-independent tablet disintegration for effective API release, and features powder flow characteristics necessary to enhance dosage form weight uniformity and throughput in DC.

Benefits

  • Excellent compactibility
  • Excellent flowability
  • Fast, hardness-independent tablet disintegration for effective API release
  • Low friability
  • Overcomes individual ingredient compaction and handling limitations

Areas of Application

  • Direct compression
  • ODT formulations
  • Dry granulation (Roller compaction, slugging)

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  • Dry granulation
  • Direct compression
  • Roller compaction
  • Co-processed Excipients
  • Oral Solid Dose
  • Orally disintegrating tablet (ODT)
  • Placebo tablet
  • Low to medium dose DC formulation
  • Tablet

20kg – Carton box with PE-EVOH-PE inliner

24 months

Wasserburg am Inn, Germany

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Typical particle size distribution

Typical Product Data

  • x10: 57 µm, x50: 176 µm, x90: 283 µm
  • Span [(x90-x10)/x50]: 1.28
  • Density bulk: 0.461 g/ml
  • Density tapped: 0.545 g/ml
  • Hausner Ratio: 1.18
  • Carr’s Index: 15 %

Specified Product Data

Particle size distribution

Sieve Method: Air-jet sieving

  • <32 µm: NMT 15%
  • <160 µm: 35-65%
  • <250 µm: NLT 85%

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MicroceLac® Plus combines lactose and MCC for exceptional tabletability. It outperforms conventional excipients – even with high drug loads.

StarLac® combines lactose and starch to support the development of soft tablets with fast disintegration – ideal for ODT formulations.

Retalac® enables direct compression of modified release formulations – combining compactibility with sustained release functionality.

We are experts in co-processed excipients – feel free to contact us for your custom formulation needs.

Looking for a customized lactose solution? We develop tailored formulations in close collaboration with you, ensuring full compliance with your specific requirements.

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