Meggle Excipients & Technology
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Cellactose® 80

Lactose and Cellulose are very well established excipients. Both are naturally derived and frequently used as diluent/binder in oral dosage formulations (ODT).

In an effort to obtain synergistic effects, such as improved tablet hardness and adherence capacity, by co-processing both excipients, spray-drying was used in order to bring lactose and cellulose together.

As a result Cellactose® 80, a co-processed excipient, was achieved that provides capability for direct compression, due to given flowability and compactability. Cellactose® 80 is made up of 75 % alpha-Lactose-monohydrate and 25 % powdered cellulose.
Particle size distribution
[Air jet sieve]

  • <32 µm: NMT 20%
  • <160 µm: 35-65%
  • <250 µm: NLT 80%
Typical Values
  • Bulk Density [g/l]: 370
  • Tapped Density [g/l] : 490
  • Hausner factor: 1.32
  • Carrs index: 24.49 %
Cellulose Lactose_Tablet hardness_low friability_sticking picking_content uniformity
Benefits
  • Good content uniformity due to low segregation tendency of the active ingredient
  • Smooth surface of the resulting cores for easy and economical coating
  • Compaction of delicate active ingredients due to excellent compactability
  • Consistent tablet hardness through constant lactose/cellulose ratio
  • High weight consistency at all compaction speeds
Areas of Application
  • Cellactose® 80 is primarily designed for direct compression. In comparison with its corresponding physical blend.
  • Cellactose® 80 provides improved tablet hardness, superior flowability and adherence capacity that prevents segregation of blended API and excipient.
  • Due to its adherence capacity Cellactose® 80 can be used in low dosage formulations. Cellactose® 80’s superior hardness yield enables its use in high dosage formulations,  as well.
Typical particle size distribution (PSD) ofsomething new Batch to batch consistency (B2B) ofsomething new
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