Lactose and microcrystalline cellulose are very well established excipients. Both are naturally derived and used frequently as diluents/binder in oral dosage formulations (ODT).
In a effort to obtain synergistic effects, such as improved tablet hardness and adherence capacity, by combining both excipients, spray-dyring was used in order to bring Lactose and Microcrystalline cellulose together. As a result MicroceLac® 100, a co-processed excipient, was achieved, that provides capability for direct compression, due to given flowability and compactability.
MicroceLac® 100 comprises 75 % alpha-lactose monohydrate and 25 % microcrystalline cellulose (MCC), both maintaining their individual chemical identities.
Particle size distribution
[Air jet sieve]
- <32 µm: NMT 15%
- <160 µm: 45-70%
- <250 µm: NLT 90%
- Bulk Density [g/l]: 460
- Tapped Density [g/l] : 580
- Hausner factor: 1.26
- Carrs index: 20.69 %
- Good content uniformity due to low segregation tendency of the active ingredient
- Smooth surface of the resulting cores for easy and economical coating
- Compaction of delicate active ingredients due to excellent compactability
- Consistent tablet hardness due to constant lactose/cellulose ratio
- High weight consistency at various tabletting speed.
Areas of Application
- MicroceLac® 100 is primarily designed for direct compression.
- In comparison with its corresponding physical blend MicroceLac® 100 provides improved tablet hardness, superior flowability and higher adherence capacity, that prevents segregation of a blended API and excipient.
- Due to its adherence capacity MicroceLac® 100 can be used in low dosage formulation. MicroceLac® 100’s superior hardness yield enables its use in high dosage formulations as well.