Reta M^®

Reta M® is the first hypromellose/mannitol-based, co-processed excipient specifically designed for DC and dry granulation of modified release formulations. To minimize development time, API dissolution prediction as a function of tablet geometry is possible. This is aided by Reta M®’s dramatic improvement in wettability compared to HPMC alone or in traditional wet granulations and simple admixtures.

MEGGLEs co-processed excipient, Reta M^®, appears as a white, or almost white odorless powder, which is freely flowing and partially soluble in cold water. It comprises equal parts of hypromellose (HPMC) with a nominal viscosity of 4000 mPa·s, together with Mannitol.

Shelf life / Retest:
24 month

Standardverpackung:
15 kg - Carton box with PE-EVOH-PE-Inliner

Распределение частиц по размерам
[Mechanical sieve shaker]

<63 µm: NMT 30%
<250 µm: NLT 80%

Типичные значения

Насыпная плотность [г/л] 400
Плотность при уплотнении [г/л]: 510
Угол откоса: 38 °
Число Гауснера: 1.28
Индекс Карра: 21.6 %

HPMC Hypromellose Mannitol_Sustained Release_modified release_direct compression

Преимущества

- All-in-one excipient which enables manufacture of

sustained drug release (time release) tablets by direct compression

- Prolonged drug release up to 13 hours

- High loading capability up to 50 % drug load

- Pharmacopoeial quality

- Lactose-free

Области применения
- Tabletting - Direct Compression, also for multi unit and mini tablets
- Tabletting - Roller Compaction
- Preparation of aqueous HPMC-formulations (thickener)
- Spheronization, Extrusion

Распределение частиц по размерамsomething new