Lactose and Cellulose are very well established excipients. Both are naturally derived and frequently used as diluent/binder in oral dosage formulations (ODT).
In an effort to obtain synergistic effects, such as improved tablet hardness and adherence capacity, by co-processing both excipients, spray-drying was used in order to bring lactose and cellulose together.
As a result Cellactose® 80, a co-processed excipient, was achieved that provides capability for direct compression, due to given flowability and compactability. Cellactose® 80 is made up of 75 % alpha-Lactose-monohydrate and 25 % powdered cellulose.
Shelf life / Retest - Standard Packaging
36 months - 20 kg Paper bag with PE-EVOH-PE Inliner
36 months - 20 kg Carton box with PE-EVOH-PE Inliner
Particle size distribution
[Air jet sieve]
- <32 µm: NMT 20%
- <160 µm: 35-65%
- <250 µm: NLT 80%
- Bulk Density [g/l]: 370
- Tapped Density [g/l] : 490
- Hausner factor: 1.32
- Carrs index: 24.49 %
- Good content uniformity due to low segregation tendency of the active ingredient
- Smooth surface of the resulting cores for easy and economical coating
- Compaction of delicate active ingredients due to excellent compactability
- Consistent tablet hardness through constant lactose/cellulose ratio
- High weight consistency at all compaction speeds
Areas of Application
- Cellactose® 80 is primarily designed for direct compression. In comparison with its corresponding physical blend.
- Cellactose® 80 provides improved tablet hardness, superior flowability and adherence capacity that prevents segregation of blended API and excipient.
- Due to its adherence capacity Cellactose® 80 can be used in low dosage formulations. Cellactose® 80’s superior hardness yield enables its use in high dosage formulations, as well.